In more detail, CMV pp65 RNA-pulsed dendritic cells (DCs) were generated from the peripheral blood of patients with newly diagnosed glioblastoma, and stimulated CMV-specific CD4+ and CD8+ effector T cells were able to kill autologous tumor cells and autologous DCs pulsed with total tumor RNA with a CMV pp65-restricted killing mechanism. This evidence concerns the gene CD4 and glioblastoma.