CGAS and neoplasm: Cyclic GMP-AMP synthase (cGAS) has been identified as a major innate immune sensor for cytosolic DNA derived from a wide range of pathogens—including HSV—as well as tumor cells, and activates the stimulator of interferon (IFN) genes (STING) to induce the expression of type I IFNs and other immune modulatory molecules [89].