Consistent with the notion that ERK5 may have important biological functions in both early and late stage brain tumours, ERK5 was recently identified as an important regulator of diffuse intrinsic pontine glioma (DIPG) cell growth within orthotopic xenograft models, through stabilisation of the proto-oncogene transcription facto MYC [39]. The gene discussed is MYC; the disease is diffuse intrinsic pontine glioma.