Our studies demonstrate productive infection of EHDV-TAU in cells with defective IFN/antiviral responses, e.g. the absence of JAK1 expression/function in LNCaP prostate cancer cells [120,167], or the low basal expression levels of PRRs and defective induction of IFN (following viral infection) by B16F10 murine melanoma cells [152]. Here, JAK1 is linked to melanoma.