Indeed, we explored the complete absence of IFN signaling in LNCaP prostate cancer cells [120,121], which also present oncogenic KRAS mutation [166], to select an oncolytic mutant of the epizootic hemorrhagic disease virus (EHDV), an orbivirus (arbovirus of the Reoviridae family) that naturally targets ruminants, and that we named EHDV-Tel Aviv University (EHDV-TAU) [120]. Here, IFNA1 is linked to Familial prostate cancer.