The expression of inflammatory mediators, such as IL-1β, IL-6, prostaglandin E2 (PGE2), granulocyte macrophage colony-stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF), is increased in the tumor microenvironment, thus recruiting MDSCs in the plasma to the site of inflammation and inducing their activation. The gene discussed is IL6; the disease is neoplasm.