PTEN and hepatocellular carcinoma: TLR4 deficiency ameliorated HCC’s burden in several HCC mouse models, including the diethylnitrosamine (DEN) and carbon tetrachloride (CCl4) induction model, or the mice with knocked-out genes encoding the hepatocyte-specific transforming growth factor-β-activated kinase 1 (TAK1), phosphatase, or the tensin homolog (PTEN) [51,52,53].