An analysis of prostates from patients treated with radiation therapy showed an increased expression of BAX in prostate intraepithelial neoplasia versus normal glands in the same patient [112], and an increased expression of BAX was associated with poor outcomes [113], yet a mechanistic basis of increased BAX expression is unclear and the role of BAX in prostate cancer remains open. This evidence concerns the gene BAX and prostate intraepithelial neoplasia.