Multiple signaling pathways induced by EGF, G-protein coupled receptors (GPCR) agonists, PMA, Galectin3, omega3- fatty acids, clusterin and α2-macroglobulin as well as by the loss of PTEN or hyperactive protein kinases have been connected to BAD phosphorylation in prostate cancer [126,127,128,129,130,131,132,133,134]. This evidence concerns the gene PTEN and Familial prostate cancer.