INS and metabolic syndrome: Other metabolic abnormalities, such as non-alcoholic steatohepatitis [77,92,93,94,95], hepatic diseases [96,97,98,99], polycystic ovarian syndrome [100], and metabolic syndrome [101,102], as well as aging [78,103,104] and ethnicity [105,106,107,108,109,110,111], have also been linked to reduced insulin clearance.