COL11A1 and pancreatic ductal adenocarcinoma: Furthermore, using IHC, it has been confirmed that COL11A1 is also upregulated in conjunction with other ECM proteins that promote collagen organization and ECM stiffness (fibronectin, cathepsin B, and cartilage oligomeric matrix protein), in three tissue microarrays from triple-negative breast cancer (TNBC), pancreatic ductal adenocarcinoma (PDAC), and diffuse large B-cell lymphoma [45].