In another study by Lim et al. (2018) [73], the authors report that across 10 tested cancer types, the COL11A1-matrisome signature was associated with a general trend toward abundance of M0 and M1 macrophages, neutrophils, activated mast cells, regulatory T cells (Treg), and T follicular helper (Tfh) cells, activated CD4+ memory T cells, and a decrease of resting CD4+ memory T cells, mast cells, naïve B cells, and resting dendritic cells. This evidence concerns the gene CD4 and cancer.