The authors of this study also demonstrate that COL11A1 also upregulates expression of TWIST1 (an EMT-promoting transcription factor [96]), and Mcl-1 (a Bcl-2 family pro-survival protein [97]), and GAS6 (a secreted protein promoting cancer cell proliferation [98]), through upregulation of IKKβ and subsequent activation of NFκB in several human ovarian cancer cell lines [62]. The gene discussed is TWIST1; the disease is cancer.