One meta-analysis showed that acutely relapsed patients with schizophrenia have increased levels of peripheral interleukins (IL) including IL-6, IL-8, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) but reduced levels of IL-10 when compared with healthy controls (Miller et al., 2011). This evidence concerns the gene IL10 and schizophrenia.