However, adjustment for serum HDL-cholesterol levels did not attenuate the effect size or significance of the associations between ApoE4/ApoE4 genotype and SARS-CoV-2 infection among the unmatched (OR, 2.27; 95% CI, 1.56–3.30; P = 1.6 × 10−5) and matched (OR, 3.15; 95% CI, 1.75–5.68; P = 1.4 × 10−4) data sets or mortality because of COVID-19 among the cases (OR, 2.57; 95% CI, 1.31–5.05; P = 6.0 × 10−3) (Table 4). The gene discussed is APOE; the disease is COVID-19.