Exclusion of subjects with dementia or Alzheimer's disease also yielded directionally consistent, but slightly attenuated, association of ApoE4/ApoE4 genotype with SARS-CoV-2-related outcomes after adjustment for HDL-cholesterol levels (supplementarl Table S4), suggesting these results were not confounded by Alzheimer's disease or dementia. The gene discussed is APOE; the disease is Alzheimer disease.