Using the same approach, we estimated the selection coefficient of another mutation, TYK2 I684S, a missense variant that is neither in linkage disequilibrium with P1104A nor associated with TB risk,11 and found values that were compatible with neutrality (s = 0.02; 95% CI [0–0.19]; Figures S7A and S7B). The gene discussed is TYK2; the disease is tuberculosis.