The subjects with significant depressive symptoms (e.g., CES-D ≥ 16 and CES-D ≥ 21) and with significant anxiety symptoms (e.g., HAM-A ≥ 18 and HAM-A ≥ 25) had higher adiponectin levels than those without depression and anxiety (i.e., CES-D < 16 and with HAM-A < 18) (Fig 1B and 1C). This evidence concerns the gene ADIPOQ and major depressive disorder.