These results suggest that higher adiponectin levels and lower leptin levels may serve as the potential markers related to clinically significant depression symptoms (e.g., CES-D ≥ 16 and CES-D ≥ 21) and anxiety symptoms (e.g., HAM-A ≥ 18 and HAM-A ≥ 25) in postmenopausal population. Here, LEP is linked to major depressive disorder.