Although in this analyses, these factors age, adiposity, hormonal and behavioral risk factors (e.g., diet, smoking status, alcohol consumption, and physical exercise), all of which are potentially important confounders have been taken into consideration, the levels of the adiponectin and leptin were highly changed and varied by menopause stages in women at midlife with/without obesity [58]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.