REST and endometriosis: Notably, we also found a functional relevance of the elevated HOTAIR levels, showing that key components of HOTAIR-associated epigenetic regulators were also upregulated in endometriosis patients, including EZH2 and JARID2 (to form histone methyltransferase PRC2 complex), as well as LSD1 and CoREST (to form histone demethylase LSD1/REST/CoREST complex) (Fig 3B).