In the context of adrenal steroidogenesis, POR contributes to 21 hydroxylase, 17 hydroxylase, and 17,20 lyase activity; indeed, mutations in POR may lead to sexual ambiguity and adrenal insufficiency, i.e., Antley–Bixler syndrome with genital abnormalities and disordered steroidogenesis (OMIM 201750) [9, 21, 22]. Here, POR is linked to Adrenal insufficiency.