In fact, carriers of the minor alleles were significantly younger at diagnosis (11.8 ± 1.37 vs 20.0 ± 4.03 days, p < 0.05) (Fig. 1) and presented higher plasma ACTH levels (416.8 ± 82.81 vs 148.6 ± 18.43 pg/ml, p < 0.05, Fig. 1) compared to children with classic CAH carrying the wild-type CC/GG alleles. Here, POMC is linked to congenital adrenal hyperplasia.