Overexpression of fascin is associated with the poor prognosis in colorectal cancer cells and it induces doxorubicin resistance in xenografted BC cells by activating the PI3K/AKT signaling pathways (which are involved in survival and proliferation) and inhibition of pro-apoptotic genes, namely, caspase-9 and caspase-3 (Ghebeh et al. 2014; Chen et al. 2015). This evidence concerns the gene AKT1 and breast cancer.