ADM2 and cancer: While the CGRP receptor comprisesCLR and RAMP1, adrenomedullin-1 (AM1) and adrenomedullin-2(AM2) receptors form by the interaction of CLR with RAMP2and RAMP3, respectively.4 AM is a potentvasodilator that regulates blood pressure.25 While AM signaling through the AM1 receptor is requiredfor cardiovascular homeostasis,26 aberrantAM signaling is implicated in cancer development and progression.27,28 Both AM and the AM2 receptors have been shown to be upregulatedand mediate protumoral processes in many cancers,29−31 including breastand pancreatic cancers.32,33