In search of possible tools that can be used as diagnostic markers, attention has been given to the UBCH10 gene, which encodes a protein belonging to the E2 family known as Ubiquitin-conjugating enzyme E2C (UBE2C/UBCH10), regulating the cell cycle in different types of carcinomas by UPS modulation, including GBM [24]. The gene discussed is UBE2C; the disease is glioblastoma.