In particular, EGFR gene amplification has been detected in approximately ~ 40% of gliomas [57], as well as frequent mutations that generate a receptor unable to recruit this ubiquitin ligase [96]: this leads to less receptor internalization and degradation, with the signaling resulting from EGFR dimerization being an aggravating factor in gliomas [45, 97]. This evidence concerns the gene EGFR and glioma.