Our major findings for ertugliflozin were as follows: reduced risk of the pre-specified exploratory renal composite, which included a sustained 40% decline in eGFR, chronic renal replacement therapy or renal death; significantly reduced UACR compared with placebo in participants with microalbuminuria or macroalbuminuria at baseline; preserved kidney function, especially in participants with macroalbuminuria at greatest risk of DKD progression; and a renal safety profile that was consistent with the known effects of SGLT2 inhibitors. This evidence concerns the gene SLC5A2 and diabetic kidney disease.