A previous study reported cooperation between Nr4a and Ets factors in gene activation in human leukemia cells and found that NR4A1 regulates transcription by binding to enhancers that are co-enriched for Nr4a- and Ets factor-binding motifs, thereby promoting the recruitment of ERG, FLI-1 Ets factors, and p300 histone acetyltransferase (Duren et al., 2016). The gene discussed is EP300; the disease is leukemia.