MAPT and Alzheimer disease: Histopathological findings showed evident neurodegenerative effects in the form of, pyknosis and degeneration alongside excessive accumulation of beta amyloid and phosphorylated Tau proteins, which are considered hallmark pathologies of AD, as experienced in previous works using AlCl3(Ali et al., 2016; Prema et al., 2017; Singh et al., 2018).