The present study showed that ICME can efficiently inhibit AChE in a dose-dependent fashion, which allow for further therapeutic potentials in AD as the other plant product which are marketed as medications for AD as Rivastigmine and galantamine with reported acetylcholinesterase inhibitors (Munoz-Torrero, 2008; Ballard et al., 2011; Syad and Devi 2014). The gene discussed is ACHE; the disease is Alzheimer disease.