Petruccioli et al. [32] argued that the majority of LTBI cases simultaneously respond to both TB1 and TB2 antigens and that an “only to TB2” response is associated with active TB, whereas others reported that individuals with LTBI showed a higher CD8+ T cell response and that an “only to TB2” response is associated with LTBI [20], [25], [33]. This evidence concerns the gene CD8A and tuberculosis.