While some authors argued that, QFT-Plus was more sensitive compared to QFT-GIT for detecting M. tuberculosis infection, mainly due to TB2 responses [27], [28], studies comparing the QFT-Plus and QFT-GIT tests mostly revealed equivalent sensitivity and a high overall agreement between the two tests in active TB [29], [19], [20], [21]. The gene discussed is REEP5; the disease is tuberculosis.