In particular, the observed recruitment of DCs in reovirus-treated tumors correlated with the significant upregulation of genes encoding XCL5, CCL5, and FLT3LG, known chemoattractants for stimulatory DCs (sDCs), a cell type integrally important for immune responses to cancer and responsiveness to anti-PD-1 immunotherapy. Here, PDCD1 is linked to cancer.