Conclusively, we showed that hypoxia differentially regulates the expression of LIN28A at both the mRNA and the protein levels in colon cancer, and revealed that non-coding LIN28A mRNA promotes the metastasis of colon cancer cells by positively regulating the expression of METAP2 as “miRNA sponges.” The gene discussed is LIN28A; the disease is malignant colon neoplasm.