To find out if non-coding LIN28A mRNA regulates the expression of METAP2 through sponging miRNAs in colon cancer, we established Dicer knockdown cell lines (Figure 6A,B) and then evaluated the impact of over-expressed non-coding LIN28A mRNA on the expression of METAP2. The gene discussed is METAP2; the disease is malignant colon neoplasm.