In mice, expression of Poc1a is enriched in the seminiferous tubules and Sertoli cells, and LINE-retrotransposon mediated deletion of Poc1a (chagun mice) mimic the human disorder and results in male infertility, due to defective meiosis in germ cells (Sarig et al., 2012; Geister et al., 2015). The gene discussed is POC1A; the disease is male infertility.