ABCD1 and X-linked adrenoleukodystrophy: In humans, loss-of-function mutations in ABCD1 affect the VLCFA degradation process, leading to a pathogenic accumulation of saturated C24–C26 VLCFAs in the plasma, brain, adrenal grand, and other tissues (Moser, 1997), causing myelopathies, as reported for the X-linked adrenoleukodystrophy (X-ALD) and the adult form, the Adrenomyeloneuropathy type (Moser, 1997).