In the GO category “basement membrane”, Col4a3, Loxl1, Timp2 and Timp3 were identified as reduced mRNA candidates, which is relevant to the lens capsular defects observed in Tdrd7-defcient lenses, especially because COL4A3 (Collagen Type IV Alpha-3) and LOXL1 (lysyl oxidase-like 1) mutations are associated with cataract and glaucoma in humans (Thorleifsson et al., 2007; Uzak et al., 2013). The gene discussed is TIMP3; the disease is glaucoma.