In the children with obesity group, age, and sex-corrected multivariate regression analysis showed that the BMI (P partial = 0.0074), waist circumference (P partial = 0.0057), serum insulin (P partial = 0.0014), HOMA-IR (P partial = 0.0009), TG (P partial = 0.0287), HDL-c (P partial = 0.0369), and Apo A1 (P partial = 0.032) were independent predictive factors for ALT. The gene discussed is INS; the disease is obesity disorder.