However, another study has found that erastin selectively targets certain genotypes in Ras-mutant cell lines, including H-Ras-mutant-engineered cells, N-Ras-mutant HT1080 human fibrosarcoma cells, and K-Ras-mutant Calu-1 non-small-cell lung cancer cells (190). This evidence concerns the gene KRAS and non-small cell lung carcinoma.