Reportedly, the small-molecule SMAC mimetic BV6 could antagonize cIAPs to overcome apoptosis resistance by inducing necroptosis upon caspase inhibition and sensitize acute myeloid leukemia (AML) cells to cytarabine-induced cell death, which could be significantly inhibited by NEC1 or MLKL inhibitor necrosulfonamide but not by caspases inhibitor Z-VAD-FMK (150). This evidence concerns the gene PCSK1 and acute myeloid leukemia.