It has been observed that GSDMD is downregulated in gastric cancer, which significantly promotes the proliferation of cancer cells in vivo and in vitro by enhancing extracellular signal-regulated kinase, STAT3, and phosphatidylinositol 3 kinase/protein kinase B signaling pathways, and regulating cell cycle-related proteins (239). The gene discussed is GSDMD; the disease is cancer.