TNF and cancer: To date, lots of molecules have been identified as triggers of necroptosis, including (but not limited to) TNF (6), CD95L (also known as FASL) (6), TNF-related apoptosis-inducing ligand (6), TNF-related weak inducer of apoptosis (41), CD3/CD28 (42), DNA-dependent activator of IFN-regulatory factors (43), and anti-cancer drugs (such as shikonin) (44).