There are a variety of chemotherapy drugs that have been found to induce pyroptosis by activating GSDME in lung cancer cells, gastric cancer cells, melanoma cell lines, SH-SY5Y neuroblastoma cells, and MeWo cells, including doxorubicin, actinomycin-D, bleomycin, 5-fluorouracil, cisplatin, paclitaxel, topotecan, and etoposide (101, 253–255). Here, GSDME is linked to melanoma.