Accordingly, both loss of RIPK3 in the tumor microenvironment and loss of the kinase activity in RIPK1 have been reported to reduce tumor nodules in the lung in murine B16.F10 primary melanoma tumors, which further implies that RIPK3 and RIPK1 are fundamental for cancer growth and metastasis (137). This evidence concerns the gene RIPK1 and neoplasm.