The subgroups include proliferation genes (Ki67, STK15; Survivin, CCNB1, MYBL2), invasion genes (MMPP11, CTSL2), HER2 genes (GRB2, HER2), estrogen genes (ER, PGR, BCL2, SCUBE2), and other cancer related genes (GSTM1, CD68, BAG1). The gene discussed is GRB2; the disease is cancer.