As presented in Table 3, both EZH2 and NSD2 protein expression correlated with pathological grade of tumor and lymph node metastasis; the high grade and positive lymph node involvement were associated with increased rate of positive EZH2 and NSD2 (P < 0.001, P = 0.003). Here, NSD2 is linked to metastatic malignant neoplasm in the lymph nodes.