The inhibition of the Notch pathway caused a significant reduction in transcription of several stem cell marker genes, including ALDH, CD24, LGR5, SOX2 and TWIST1. Furthermore, patient-derived xenograft models clearly demonstrated that inhibition of Notch signaling by gamma-secretase inhibitors is efficacious in downsizing tumor growth (42). The gene discussed is SOX2; the disease is neoplasm.