Decreases the expression of stem cell signaling markers such as Jagged1, Shh, YAP1 in both OAC and OSCCEffectively downregulates mTOR components including phospho-AKT, phospho-S6, phospho-70S6 in both OAC and OSCCInhibits the growth of carcinoma cells in vitro and in vivo in both OACand OSCC. The gene discussed is SHH; the disease is carcinoma.