YAP1 plays a significant role in the maintenance of stemness of embryonic stem cells as well as contributing to the functions of CSCs (80–82).Therefore, deregulation of Hippo and activation of YAP1 in CSCs contributes many important properties of tumors, and thus, targeting YAP1 will be an effective strategy to target CSCs, thereby inhibiting tumor growth. The gene discussed is YAP1; the disease is neoplasm.