Especially, CDCAs are significantly up-regulated in HCC: CDCA1 (log2FC = 3.72, adjusted P = 6.70E-46), CDCA2 (log2FC = 2.76, adjusted P = 1.4E-29), CDCA3 (log2FC = 2.92, adjusted P = 1.96E-39), CDCA5 (log2FC = 3.15, adjusted P = 2.603E-45), CDCA6 (log2FC = 2.12, adjusted P = 3.79E-21), CDCA7 (logF2C = 2.29, adjusted P = 3.40E-10), and CDCA8 (log2FC = 2.86, adjusted P = 3.21E-39). The gene discussed is CBX2; the disease is hepatocellular carcinoma.