Among them, seven genes of CDCAs (34) (CDCA1/NUF2: P = 2.73E-22, CDCA2: P = 1.52E-16, CDCA3: p = 1.50E-20, CDCA5: P = 1.77E-20, CDCA6/CBX2: P = 6.87E-19, CDCA7: P = 5.92E-16, and CDCA8: P = 1.67E-18) were all up-regulated in 19 cancer datasets (Figure 2). The gene discussed is CDCA2; the disease is cancer.