INS and type 2 diabetes mellitus: Another randomized placebo-controlled study conducted in patients with T2DM for more than 10 years duration, who were on metformin and insulin therapy, had glimepiride added, and an effective lowering in HbA1c level with minor hypoglycemic events even after the long duration of T2DM was observed [12]. These studies support the findings from the current study offering an effective therapeutic option for patients not responding to the combination or other drug combinations. Newly diagnosed patients successfully attain glycemic control with monotherapy or a multiple oral drug combination.