MAD2L1 was reported to exert oncogenic effects in gastric cancer (Wang et al., 2019b) and lung cancer (Guo et al., 2010), as well as HCC by regulating the malignant behaviors of tumor cells (Foijer et al., 2017; Li, Bai & Zhang, 2017). The gene discussed is MAD2L1; the disease is neoplasm.