To validate the mRNA expression levels of the screened hub genes between HCC and normal hepatic tissues, a meta-analysis on the mRNA expression levels of BUB1B, CCNB1, CCNB2, CDC20, CDK1, MAD2L1 and RRM2 was performed based on the ONCOMINE database. This evidence concerns the gene CCNB2 and hepatocellular carcinoma.