EGFR and non-small cell lung carcinoma: Osimertinib and erlotinib reduced DR4 levels accompanied with the induction of apoptosis (e.g., PARP cleavage) in the sensitive EGFRm NSCLC cell lines, but not in insensitive NSCLC cell lines with wild-type EGFR or resistant EGFRm NSCLC cell lines.