Two recent studies have suggested that TRAIL death receptors including DR4 mediate the production of inflammatory cytokines such as CCL2/MCP1, IL-8 and CXCL1 induced by TRAIL in TRAIL-resistant cancer cell lines through facilitating the formation of a “FADDosome” complex primarily consisting of caspase-8, FADD and RIPK1 and subsequent NF-κB signaling activation 32, 33. The gene discussed is CCL2; the disease is cancer.