We noted that both osimertinib and erlotinib did not suppress ERK phosphorylation, induce PARP cleavage or decrease DR4 levels in wild-type (WT) EGFR NSCLC cell lines (H226 and H596; Figure 1E), EGFRm NSCLC cell lines with acquired resistance to osimertinib (PC-9/AR and HCC827/AR; Figure 1F) or the EGFRm PC-9 cell line engineered with T790M and C797S mutations that confer resistance to osimertinib (PC-9/3M; Figure 1G). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.