It is striking to see the lack of research regarding targeting of PDGFRs in canine melanoma, HER2 in canine invasive TCC, CXCR4 in mammary carcinoma and IGF-1R in canine osteosarcoma, all highly expressed molecular targets whose targeting is being evaluated in the human clinic for the respective malignancies. The gene discussed is ERBB2; the disease is tarsal-carpal coalition syndrome.