For instance, the H3K9me2/3 demethylase JMJD2D was able to promote liver cancer initiation and progression independent on its demethylase activity, instead, JMJD2D directly interacted with p53 and inhibited p53 recruitment to the p21 and PUMA promoters, implicating a demethylase-independent function 48. This evidence concerns the gene KDM4D and liver cancer.