In addition, we observed significantly greater infiltration of macrophages in somatotroph adenomas (SAs) and prolactinomas (PRLs) than in nonfunctioning pituitary adenomas (NFPAs) and adrenocorticotropic hormone (ACTH) adenomas (P < 0.05, Figure 2B). The gene discussed is POMC; the disease is growth hormone secreting pituitary adenoma 1.