As shown in (Figure 4A-C), mEPSC frequency was significantly decreased in SH-treated mice subjected to stroke compared to sham-operated mice, exposure to EE reversed the stroke-induced decrease in mEPSC frequency, and NO-711 abolished the promotion effect of EE on mEPSCs, indicating that GAT-1 is critical for EE-induced input synaptic strengthening in the peri-infarct cortex. This evidence concerns the gene SLC6A1 and Stroke.