To test whether HDAC2 regulates the expression of GAT-1, LV-shHDAC1 or LV-shHDAC2 was microinjected into the motor cortex of mice 3 days before stroke to specifically knockdown peri-infarct HDAC1 or HDAC2, and immunoblotting was performed 5 days after stroke. The gene discussed is HDAC1; the disease is stroke disorder.