Altogether, these results indicated that EZH2 and its catalytic histone mark-H3K27me3 were deposited at the core promoter region of CDKN2B gene, strongly demonstrating that CDKN2B (p15INK4b) is a direct transcriptional target of EZH2 in CRC cells. The gene discussed is CDKN2B; the disease is colorectal carcinoma.