Previous work has shown that BRD7, SUZ12 and PRMT5 co-localize on ST7 and retinoblastoma-like protein 2 (RBL2) promoters, and that their association with these target tumor-suppressor genes correlates with methylation of H3R8, H4R3 and H3K27 in patient-derived mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) cell lines 27. The gene discussed is RBL2; the disease is B-cell chronic lymphocytic leukemia.