Even though a cohort of cell cycle-related genes, including CDKN1A (p21CIP1/WAF1), CDKN2C (p18INK4C), CDKN1C (p57KIP2), p63 and PTEN, were identified as PRMT5 targets in gastric cancer by Liu and colleagues, PRMT5 depletion did not appear to affect the expression of CDKN2B, implying that the mechanisms by which PRMT5 regulates cancer cells in CRC and gastric cancer are different 10. This evidence concerns the gene CDKN1A and cancer.