To establish MDO models, we considered a total of 10 patients with metastatic RCC treated between January 2017 and December 2019 at Ruijin Hospital, and selected 3 CT-guided needle lung biopsies with low expression of METTL14 (H-scores < median 18.2) (Figure 7B). This evidence concerns the gene METTL14 and renal cell carcinoma.