Our results are agreement with recent evidence from studies on several adipose-specific KO mouse models, such as lysine-specific demethylase 1 (Lsd1) 51, adipose triglyceride lipase (ATGL) 52, and mitofusin2 (Mfn2) 53, 54 adipose-specific KO mouse models, all of which revealed impaired thermogenesis in BAT but resistance to HFD-induced insulin resistance. The gene discussed is PNPLA2; the disease is Insulin resistance.