Recently, aberrant overexpression of PDK-1 has been associated to poor prognosis and liver metastasis in colorectal cancer 5 and some reports show that liver-metastatic breast cancer cells also display high expression of PDK-1, strongly pointing out to a key role of this enzyme in liver metastasis independently of the origin of the primary tumor 6. The gene discussed is PDK1; the disease is colorectal cancer.