Mutated KRAS is reported in approximately 35%-45% of colorectal cancers and >90% of pancreatic ductal adenocarcinoma (PDAC) correlating with abnormal metabolic rates, enhanced glucose uptake and resistance to EGFR-targeted therapies as well as preoperative chemoradiotherapy (CRT) 8-10. The gene discussed is KRAS; the disease is colorectal cancer.