Cluster 2 (20 patients with PCNSL and 25 patients with DLBCL) was enriched in a higher number of lymphoid cells, e.g., activated CD4+ and CD8+ T cells, regulatory T cells (Tregs), and myeloid cells such as TAMs, myeloid-derived suppressive cells (MDSCs), or activated dendritic cells (DCs). This evidence concerns the gene CD8A and primary central nervous system lymphoma.