CD274 and neoplasm: Most notably, anti-PD-1 antibodies have been approved for therapy of relapsed/refractory classical Hodgkin's lymphoma (HL) harboring increased PD-1+ tumor-infiltrating lymphocytes (TILs), high PD-L1 expression, and 9p21.1 (PD-L1 gene locus) copy number alteration 6.