ALDH1A1 and cancer: The build-up of aldehydes in ovarian cancer cell lines following treatment with 673A is consistent with a study by Pérez-Alea et al, 2017, which demonstrated that treatment of cancer cells with the irreversible isoform-specific ALDH1 inhibitor DIMATE, or down regulation of ALDH1A1 and ALDH1A3, resulted in an accumulation of aldehydes 30.