DENND1A and polycystic ovary syndrome: For instance, the gene showing the strongest and widest selection signature (i.e., DENND1A) plays a role in the development of polycystic ovaries, anovulation, and hyperandrogenism that mainly characterize the polycystic ovary endocrine syndrome (Chen et al., 2011; Ha et al., 2015; Shi et al., 2012).