Among them, the CREB1, ATF2, PPARGC1A, and CPT1C genes are indeed known to modulate insulin resistance in the adipose tissue of obese individuals (Gao et al., 2009; Maekawa, Jin, & Ishii, 2010; McCarty, 2005; Qi et al., 2009). Here, CREB1 is linked to Insulin resistance.