Li et al. (2018) have found that FTO is involved in insulin defects-related Alzheimer’s disease mice through activating TSC1-mTOR-Tau signaling. In the neurons of mice, m6A RNA demethylase ALKBH5 was recently found to be widely expressed (Du et al., 2020). The gene discussed is FTO; the disease is early-onset autosomal dominant Alzheimer disease.