Furthermore, we analyzed specific mutated genes among colon cancer samples and found the top 10 mutated genes, including TTN (49%), APC (75%), MUC16 (27%), SYNE1 (29%), TP53 (55%), KRAS (43%), FAT4 (23%), RYR2 (21%), PIK3CA (28%), and ZFHX4 (21%), which might play important roles in colon cancer biological processes (Figure 1F). This evidence concerns the gene RYR2 and malignant colon neoplasm.