APC and malignant colon neoplasm: Additionally, we found the top mutated genes and their interactions, including APC, TP53, TTN, and KRAS, suggesting their critical roles in colon cancer carcinogenesis (Figures 1F, 2) (Kwong and Dove, 2009; Wolff et al., 2018; Nakayama and Oshima, 2019).