Bruck Syndrome (BRKS) is a rare type of recessive osteogenesis imperfecta (OI) and consists of two subtypes, BRKS1 and BRKS2, which are caused by variations in <i>FKBP10</i> and <i>PLOD2</i> genes, respectively. This evidence concerns the gene PLOD2 and osteogenesis imperfecta.