DAP and cervical carcinoma: Chen et al. (2013) performed the first genome-wide association study (GWAS) of cervical cancer and identified three independently acting loci (DAP, NR5A2, and MIR365-2 gene regions) within the major histocompatibility complex (MHC) region contributing to the risk of developing cervical cancer, which support its role in high-risk HPV infection and persistence.