CDA and cervical carcinoma: Mutational signatures of cervical cancer were enriched in deficiency of DNA mismatch repair (COSMIC Signature 6; cosine similarity: 0.895), APOBEC-cytidine deaminase (COSMIC Signature 2; cosine similarity: 0.846), and spontaneous deamination of 5-methyl cytosine (COSMIC Signature 1; cosine similarity: 0.951) (Figure 2D).