In a CRC experimental model, natural polyphenol supplementation modulated the tumor-associated immunosuppressive microenvironment and inhibited the growth of CRC cells by reducing the colonic infiltration of CD3+ T cells and the number of CD25-FoxP3 regulatory T cells, increasing the mucosal CD4+ T and B cells (89–92). Here, FOXP3 is linked to colorectal carcinoma.