CASP3 and colonic neoplasm: Hu et al. reported that PPEP, a polyphenol-rich extract isolated from edible mushrooms, effectively downregulated the expression of cell cycle-related signaling proteins (e.g., cyclin B and cyclin E) and upregulated the expression of cell apoptosis-related signaling proteins (e.g., caspase-3) in human colon cancer cells, which further caused considerable cell cycle arrest and cell apoptosis (68).