CCND3 and diabetes mellitus: We monitored the spontaneous incidence of diabetes in these two experimental groups and observed that regardless of the CDK11 hemideficiency, the Cyclin D3 deficiency had a dominant effect on the onset of diabetes and exacerbated the disease compared to normal NOD mice (K11WT-D3WT) since the CDK11 hemideficiency did not alleviate the T1D in the Cyclin D3 deficient mice (Figure 4).